P-223 Comparison of blastocysts’ iDAScore® (intelligent Data Analysis-Score) if in vitro fertilization is performed using ICSI instead of IMSI

Abstract Study question Does blastocysts’ iDAScore® differs when ICSI is performed instead of IMSI in case teratozoospermia on the day vitro fertilization (D0)? Summary answer Blastocysts’ unchanged or at (D0). What known already In routine practice, for D0-teratozoospermia sometimes not because its higher cost and/or laboratory workload. Time-Lapse studies have shown that (IVF) using suboptimal sperm parameters lead to morphokinetically similar embryos. However, patients with oligoasthenoteratozoospermia/teratozoospermia, evidence indicate may improve embryo morphokinetics and further clinical outcomes. Since these rely morphokinetical features assessed by an embryologist, use artificial intelligence limit human subjectivity choosing optimal blastocyst transfer. Whether impact has never been investigated. design, size, duration This retrospective monocentric study was between September 2021 December 2022 our reproductive medicine unit. A total 605 oocytes (386 ICSI, 219 IMSI) from 58 (37 21 were fertilized fresh either then incubated 5 days Embryoscope8 (Vitrolife®) combined iDAScore®. iDAScores® 325 blastocysts (228 97 compared arms. Participants/materials, setting, methods For each couple 3 available: i) mean all blastocysts, ii) max, iii) useful blastocysts. These scores according technique IVF used (ICSI IMSI). addition, pregnancy rates following transfer analyzed. all, 53 transfers (34 19 realized during frozen cycles. Clinical defined presence fetal heartbeat ultrasound. Main results role chance Patients groups comparable terms women age (32.3 ± 5.6 32.2 years), BMI (24.9 4.3 25 Kg/m2, respectively). rank 1.4 1.5 2.8 couples. The number mature inseminated per patient (10.9 4.7 10.4 4.6, respectively), as well (6.4 3.5 4.6 3.5) blastoformation rate (0.74 0.2 0.66 0.2, max having undergone (7.60 1.2 vs. 7.63 1.1 (p = 0.92); 8.80 8.78 1.0 0.67) 8.1 vs.7.96 1 0.77) Finally, cumulated (CPR) different (22/34 10/18 (0.65 0.49 0.55 0.46, respectively 0.53)). Limitations, reasons caution should be interpreted due design small population. Wider implications findings We observed no difference iDAScores whether D0-teratozoospermia. more time-consuming expensive, if are confirmed studies, we withdraw this indication avoid bear additional fees, especially private clinics. Trial registration applicable